Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors
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چکیده
منابع مشابه
Expression Profiles of PIWIL2 Short Isoforms Differ in Testicular Germ Cell Tumors of Various Differentiation Subtypes
PIWI family proteins have recently emerged as essential contributors in numerous biological processes including germ cell development, stem cell maintenance and epigenetic reprogramming. Expression of some of the family members has been shown to be elevated in tumors. In particular, PIWIL2 has been probed as a potential neoplasia biomarker in many cancers in humans. Previously, PIWIL2 was shown...
متن کاملgenetics of testicular germ cell tumors
testicular germ cell tumor (tgct) is the most solid tumor in 20-40 years old man. tgct account for 95% of testicular tumors and represent a unique type of human cancer from several different perspectives. tgct arise by transformation of germ cells. the transformed germ cells exhibit ploripotentially to differentiate into embryonic. extra-embryonic, and somatic tissue types, and are highly sensi...
متن کاملBilateral testicular germ cell tumors.
Testicular cancer represents 1% to 1.5% of neoplasias in males and 5% of urologic tumors in general. The incidence of bilateral testicular tumors is 1-5%. Approximately one third of the cases are diagnosed as synchronous, while the other two thirds are diagnosed as metachronous tumors. Additionally, 5% of all patients diagnosed with testicular cancer may have contralateral intratubular germ cel...
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Over the past decade, accumulating evidence has implicated the phenomenon of epigenetic dysregulation in a variety of cancers (Biermann and Steger, 2007). Defined as the heritable changes in gene function that are not attributable to changes in DNA sequence, epigenetics involve biochemical modifications to DNA regulatory elements as well as to the tail regions of histone proteins (Maekawa and W...
متن کاملTestisin, a new human serine proteinase expressed by premeiotic testicular germ cells and lost in testicular germ cell tumors.
We have cloned and characterized a cDNA encoding a new human serine proteinase, testisin, that is abundantly expressed only in the testis and is lost in testicular tumors. The testisin cDNA was identified by homology cloning using degenerate primers directed at conserved sequence motifs within the catalytic regions of serine proteinases. It is 1073 nucleotides long, including 942 nucleotides of...
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ژورنال
عنوان ژورنال: Journal of Carcinogenesis
سال: 2010
ISSN: 1477-3163
DOI: 10.4103/1477-3163.60358